MEDICAL NARRATION (BRITISH)

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Elearning
173
2

Description

Narration of educational video on the meningaccocal virus

Vocal Characteristics

Language

English

Voice Age

Middle Aged (35-54)

Accents

British (England - East Anglia, Cambridge, Hertfordshire) British (General) British (Received Pronunciation - RP, BBC)

Transcript

Note: Transcripts are generated using speech recognition software and may contain errors.
the meningococcus is a capsule ated gramme negative diplodocus responsible for meningitis and sepsis. Meningococcus be shown here is the leading cause of invasive disease in Europe, as well as other countries worldwide. Under the capsule, visible here as a gelatinous coating, is the outer membrane on whose surface on numerous proteins For the development of the vaccine against meningococcus. B four of these proteins nod a N h B A F HBP on poor A were identified and chosen by an Italian research group by means of an innovative technology. Meningococcus is transmitted from an individual to the other through saliva droplets. The transmission from a carrier or a six subject to the healthy individual is followed by the settlement in the mucosa off nose throat. On upper airways, the Mandingo Caucus adheres to the mucosal epithelium, thanks to various surface proteins, among which nod a plays a key role. Following adhesion, the meningococcus is able to cross the mucosal barrier and enter the bloodstream. Once in the bloodstream, the meningococcus begins to multiply and spread rapidly. Inside the blood vessel Factor H is abundantly present. This is a human protein that plays a key role in the alternative compliment Cascade on DH that is recognised and specifically bound by F HBP, so factor H begins to cover the surface off the meningococcus. Meanwhile, the inflammatory condition triggers the release of heparin from mast cells. Heparin is also recognised and bound by the meningococcus, in this case, thanks to the protein and H B, a heparin now bound to N H B. A binds in turn factor h, which then entirely covers the meningococcus. Through this mechanism, the meningococcus is masked and is invisible to the immune system cells such as white blood cells, which, being unable to it here cannot attack the bacterium. The meningococcus is thus free to multiply and produce the classic manifestations ofthe meningococcal disease back to re mia meningitis and septicemia. What happens instead, inside the body of an individual who has been vaccinated with the vaccine against meningococcus be aunt who is infected with the bacterium after immunisation B cells can produce protective antibodies against each of the four components off the vaccine that eh? HBP and h b A and pour a. The occasion of nada es to the mucosa is already presumably obstructed by anti nod, a mucosal antibodies summoning a ****, I may still cross the mucosal barrier that's flowing into the bloodstream. These men, Inga **** I, however, can be promptly recognised by the protective antibodies directed against each of the four angiogenic components. The bond with the antibodies prevents the men Inga caucus evasion mechanism and can activate the processes of defence against it. The antibodies which enveloped the meningococcus may therefore initiate the compliment cascade, the mechanism that will lead to their ultimate annihilation, freeing the bloodstream from the bacteria and thus avoiding the danger of disease on set.