I've been asked by several clients to voice scientific and medical scripts. My facility with vocabulary makes these a perfect fit for me.
Middle Aged (35-54)
North American, US General American (GenAm)
Note: Transcripts are generated using speech recognition software and may contain errors.
snake Catholics, it and derived peptide inhibits zika virus infection. The recently re emerged zika virus is a single stranded RNA virus and is predominantly transmitted by the widely distributed AIDS mosquitoes in nature in the past decade, the epidemic potential of the zika virus likely increased with its emergence in the pacific Americas and asia zika can be classified into the african lineage and the asian origin is the recent epidemic strain. It is reported that a spontaneous mutation of the asian line enhanced the infectivity of the zika virus in a DS aegypti mosquitoes. Despite some differences between the two lineages, the epidemic zika virus seems to have shifted from mild, self limited pathogenesis to a severe neuro virulent virus. However, it should be noted that zika virus infection can cause severe neurological symptoms and fetuses, neo Nate's and adults. Additionally, zika can be detected in human body fluids and may be transmitted through sexual activities. Moreover, it has been demonstrated that the virus can induce inflammation in the mouse testes and leads to male infertility. Therefore, controlling zika virus epidemics is a daunting challenge. While vaccination is the primary strategy for preventing zika virus infections, there is no approved drug or vaccine. Still antivirals may play an essential role in controlling zika virus infection and transmission at present. Repurposing approaches have identified many FDA approved drugs and their anti zika virus activities have been tested in vivo. Some had been approved for clinical trials while others were dismissed recently due to their weak activity or undesirable toxicity, interestingly animal venoms are also important resources of novel drugs, Catholics it in B. F Or B. F. 30 is a defensive peptide identified from Hungary's fascist status or the banded Crites snake venom and it's an excellent template for applicable peptide design. These natural animal host defense peptides uniquely evolved to protect the hosts have been shown to hold anti viral properties, with previous studies showing BF 30 having strong activities against acne bacteria and influenza A infections. Although peptide antivirals have gained more attention, certain factors limit their clinical application. While much of the progress has been made in designing artificial anti zika virus peptides, a better understanding has enhanced the development of natural peptides derived analogs with improved pharmacological properties and reduced side effects. Previous work with BF 30 peptic analogs has shown to have therapeutic potential for vaginitis and was approved for Phase 123 Clinical study to develop vaginal effervescent tablets to treat bacterial vaginosis. In this study, human mosquito and monkey cell lines. In addition to macrophages derived from the bone marrow of mice were cultured and infected with the zika virus and without different drugs that included the BF 30 analog, Z. Y 13 and the FDA approved drug Amadiyah Queen. They found that the peptic analogs inhibit zika virus infection in vitro to test the toxicity of the analog, repeated assays on mouse pups. Found the results to suggest that they can restrict the zika infection and improve the growth defects of zika virus infected mice. Meanwhile, Z. Y. 13 should a relatively weaker effect on the replication of the Dengue virus. Mechanistic studies through viral inactivation assays pre incubating with the peptide analog revealed that Zy- 13 can directly inactivate the Zika virus and reduce the production of infectious variations by interrupting the viral membrane integrity. Further expression. Studies of relevant genes also indicated that administration of Z Y 13 strengthen the host antiviral immunity via the A. X. L. Socks or suppressor of cytokine signaling protein pathway, negatively regulates type one interferon signaling and may favor the elimination of Zika virus during the early phase of infection. Since Excel has closer links to Zika rather than other flava viruses, these findings may partially explain the different antiviral efficacy of Z. Y 13 against Zika and Dengue zika infection can result in cortical thinning and neuro development anomalies of the fetus. It is possible and necessary to evaluate the in vivo antiviral efficacy of the analog by using an appropriate mouse model. This study demonstrated that Z. Y13 could restrict the viral load in the brain and improve the growth defects of Zika virus infected mouse pups. The development of the brain of rodents is immature at birth in this sense. One day old neonatal mice brain development may correspond to that scene in the later stages of human pregnancy. Therefore it is reasonable to say that the analog may have therapeutic potential in vivo. However, a study has shown that different zika virus strains respond differently to the natural compound Sylvester. All. thus more experiments should be carried out both in vitro and in vivo by using different zika virus gina types. Recently, a study uncovered a hidden outbreak in Cuba during 2017, highlighting that Zika may still be silently spreading worldwide, presenting a threat to public health, considering there are still no approved vaccines, the development of specific drugs for zika virus infection is paramount. The promising results observed in this study suggests that Zy- 13, a representative analog of a snake venom peptide, is a promising molecule against Zika. Furthermore, the study also highlighted the usefulness of venom peptides as prototypes for antivirals development.
Doctor, Narrator, Professor, Instructor, Presenter, Articulate, Authoritative, Casual, Confident, Educational, Engaging, Informative, Intellectual, Approachable, Helpful, North American, US General American (GenAm)