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mechanism of blood clotting Clotting takes place in three essential steps. Step one it involves the formation of a complex of activated substances collectively called pro trump activator, it is formed by a complex cascade of chemical reactions that occur in the blood by the involvement of clotting factors in two pathways, intrinsic pathway and extrinsic pathway, intrinsic pathway. It occurs when the blood is exposed to collision of injured and out ilium of blood vessels. This activates factor 12 or Hagman's factor, and in turn it activates another clotting factor, which activates yet another reaction in a cascade fashion, which results in the formation of the pro trombone activator extensive factory. It occurs when the vascular wall is severely damaged and extra vascular tissue comes in contact with blood. This activates the release of tissue trauma placed in from the damaged tissues. It activates the factor seven. As a result of these cascade reactions. The final product formed is the pro thrombin activator. Pro Trump Unease Step two. The programming activity in the presence of sufficient amount of calcium ions causes the conversion of inactive pro trombone to active trauma. Step three trump in converts the soluble protein fiber notion into soluble fiber in monomers which are held together by weak hydrogen bonds. The fiber in stabilizing factor Factor 13 released from platelets replaces hydrogen bonds with covalin bonds and cross links the fibers to form a mesh work the intractable mesh work of vibrant fibers spreading in all directions are geared to the damaged surface and trapped the blood cells and platelets. Within a few minutes after the clot is formed, it begins to contract so that the fluid is expelled. This is called clot retraction, and the fluid that's form is the serum that is plasma without fiber, no gin and some other proteins.