Medical E-Learning Narration
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Description
Vocal Characteristics
Language
EnglishVoice Age
Young Adult (18-35)Accents
British (General) British (Received Pronunciation - RP, BBC)Transcript
Note: Transcripts are generated using speech recognition software and may contain errors.
The beta chain of haemoglobin is 147 residues in length. Yet a single amino acid substitution leads to sickle cell anaemia. In normal haemoglobin, the amino acid at Position seven is glutamate. In sickle cell haemoglobin, dis glutamate is replaced by a valentine. Because of this change of one amino acid in the chain, haemoglobin molecules form long fibres that distort the by concave or disc shaped red blood cells and assume a crescent or sickle shape, which clogs arteries. This can lead to myriad serious health problems such as breathlessness, dizziness, headaches and abdominal pain for those affected by this disease.