Medical Narration
Description
Vocal Characteristics
Language
EnglishVoice Age
Middle Aged (35-54)Accents
North American (General) North American (US General American - GenAM) North American (US Mid-Atlantic)Transcript
Note: Transcripts are generated using speech recognition software and may contain errors.
There are two incretin hormones, glucagon like peptide one or G LP one and glucose dependent insulinotropic polypeptide or G IP. Both are produced in the gastrointestinal tract in response to food intake. And they are responsible for about 70% of insulin secretion after meals. As illustrated by the graph on the left, we know that oral glucose leads to a greater stimulation of insulin secretion than an intravenous glucose infusion. This phenomenon is called the incretin effect and is attributed to the fact that oral glucose leads to the release of G IP and G LP one. While intravenous glucose does not as illustrated by the graph on the right, the incretin effect is markedly diminished in people with type two diabetes resulting in higher and sustained glucose plasma concentration after ingestion of carbohydrates.