Single Neuron Studies of the Human Brain
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Language
EnglishVoice Age
Middle Aged (35-54)Accents
North American (General) North American (US General American - GenAM)Transcript
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from your vantage point is a researcher just entering the field of human single neuron research. You ve already experienced the excitement and potential contributions to human knowledge inherent and directly working with the human brain. However, the neurosurgical theater of the mind often look intimidating and complex, or an environment without the reassurance of complete experimental control. Being in the operating room is an intense experience. Individuals new to this field of research may easily find themselves overwhelmed by the cast of characters, doctors, nurses and other ancillary personnel by a great variety of instruments the life support, an anesthetic machinery and the boundaries of the sterile field, and by the overwhelming presence of a patient with an exposed brain, sometimes a weight during procedures performed under local anesthesia on the hospital ward. The situation may be daunting as well, with an abundance of healthcare personnel visitors in a patient's room, the constant possibility of eminent epileptic seizures and a myriad of noise sources electrical and psychological. What advice, then I can help you as a scientist entering this complex field of single neuron recordings and humans. The first step in an organized research project would entail choosing the right question, however, contrary to the tradition of carefully preconceived lines of scientific investigation. As a researcher and this field, you need to be an experimental opportunist. You cannot choose just any question and hope to record from the relevant neurons. The sights of recordings will always be completely determined by the clinical imperative, and thus we fixed in locations that cannot be altered. The question you elect to explore has to be grounded an animal physiology and has to build on this knowledge. Yeah, the question must also be relevant and you need to the human condition in particular. You need to take what we know from non human primate neurophysiology to the next level. The human level, single neuron human neurophysiology is a small field between animal neurophysiology and human functional neuroimaging and other noninvasive methods customarily used in cognitive neuroscience. However, it's not enough to confirm findings from these areas to merely confirm results obtained from other methods is to fail to take advantage of you need opportunities for advancing knowledge afforded by the methodology of human single neuron research. You need to ask the next question the one which can only be answered using this technique