Xerbaxa Medical Narration
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North American (General) North American (US General American - GenAM)Transcript
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Welcome to the Serb Aqsa three. Graham long penetration experience in patients with hospital acquired pneumonia. H AP or Ventilator associated pneumonia v AP An antibiotic must reach therapeutic concentrations at the site of the infection. The epithelial lining fluid, also known as the E L F. Studies, to quantify penetration of antibiotics into the E L F typically involve healthy subjects, but even here in the healthy lung, there are physiological obstacles that can keep antibiotics from reaching target concentration in the e l f. An antibiotic must get through the capital ery wall, penetrate the Al Villar wall and reach the E l F all while facing elimination via Arenal clearance. These obstacles can result in a significantly lower concentration of antibiotic in the E l F compared to plasma concentration in patients with H AP or V. AP thes challenges are exacerbated by disease related changes in physiology. Inflammatory mediators act as pulmonary vessel dilator sze al veel. Our walls thicken in response to inflammation and aggressive use of I V. Fluids and vase oppressors can contribute to augmented renal clearance. Thes changes must present challenges in achieving therapeutic concentrations of antibiotic in the e L. F gearbox a three grams was studied and critically ill ventilated patients and overcame the challenges of a Zo Die elation, inflamed al viola walls and renal hyper clearance to exceed M. I see in the e l f over the entire dozing interval. Piquet or P D Data establishes that three grams of Z box A is the appropriate dose for critically ill patients with H AP or V A P. C. The data here. As you can see Zerbe Aqsa at the indicated three gram dose, achieved target concentration above the M I C over the entire dozing interval in critically ill ventilated patients. The two components of Serb Aqsa, CEFTA, Alison and Tezo backed um demonstrated similar Piquet or PT profiles. When your adult patient presents with H AP or V AP, you can fight it at the source with Zerbe Aqsa.