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Vocal Characteristics
Language
EnglishVoice Age
Middle Aged (35-54)Accents
North American (General) North American (US General American - GenAM) North American (US Midwest- Chicago, Great Lakes)Transcript
Note: Transcripts are generated using speech recognition software and may contain errors.
The amyloid hypothesis is the hypothesis that Alzheimer's disease results from an accumulation of the peptide beta amyloid, which forms plaques that cause synaptic dysfunction, inflammation and neuronal death. Amyloid precursor protein is a trans membrane protein that is a precursor to beta amyloid. Beta amyloid plaques are formed by an accumulation of the beta amyloid peptide, which is derived from a larger protein called amyloid precursor protein neurofibromatosis. Tangles are abnormal aggregates of a protein known as tau, which is normally essential in maintaining the structural integrity of micro tubules. Beta amyloid plaques are formed when amyloid precursor protein is cleaved, cut by enzymes called beta secretase and presenting them, resulting in the release of beta amyloid in the extra cellular space. These plaques accumulate on the axons and dendrites of neurons and prevent them from carrying out their functions.